![]() Repeat dosing is not supported by clinical data and is not recommended. INR greater than 6: 5000 units of Factor IXĭuration of therapy: Single dose. INR 2 to less than 4: 2500 units of Factor IX INR greater than 6: 50 units of Factor IX/kg body weight given intravenously INR 4 to 6: 35 units of Factor IX/kg body weight given intravenously INR 2 to less than 4: 25 units of Factor IX/kg body weight given intravenously Usual Adult Dose for Reversal of Acquired Coagulation Factor Deficiency: Related/similar drugs prothrombin complex Dosing information Donated plasma is tested and treated to reduce the risk of contamination, but there is still a small possibility it could transmit disease. Kcentra is made from donated human plasma and may contain viruses or other infectious agents. Tell your doctor if you are pregnant or breastfeeding. If you have had a blood-clot within the last 3 months. If possible before you receive Kcentra, tell your caregivers if you have ever had:Ī stroke, including TIA ( transient ischemic attack) or "mini-stroke" Low levels of platelets in your blood after using heparin Įxcessive blood-clotting caused by a condition called disseminated intravascular coagulation orĪ history of severe allergic reaction to prothrombin complex, Protein C or Protein S, Antithrombin III, heparin, human albumin, or Factors II, VII, IX, X. You should not be treated with Kcentra if you have: After you are treated with this medicine, do not start using your blood thinner again until your doctor tells you to. Kcentra is for use in people who use blood thinners such as warfarin. Tell your doctor if you have ever had a heart attack, stroke, TIA or "mini-stroke", chest pain, severe circulation problems, or a blood clot (especially within the past 3 months). While using Kcentra, tell your caregivers right away if you have signs of a blood clot: sudden numbness or weakness, problems with vision or speech, chest pain, cough, wheezing, rapid breathing, swelling or pain in your arms, legs, or stomach. Kcentra is for use in adults and dosing is based on body weight. Kcentra is used to quickly reverse the effects of a blood-thinning medicine (such as warfarin) during a major bleeding episode, or when there is a need for emergency surgery or invasive medical procedure. Kcentra is a blood coagulation factor replacement product. ![]() Medically reviewed by Philip Thornton, DipPharm. Generic name: prothrombin complex ĭrug class: Anticoagulant reversal agents ![]()
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